التصلب الجانبي الضموري | التصلب الجانبي الضموري

التصلب الجانبي الضموري. التصلب الجانبي الضموري...المرض المغمور الذي أصاب المشاهير!

There is a tentative association with exposure to various , including the , , , and	"Epidemiology of amyotrophic lateral sclerosis: A review of literature"
: Mayo Foundation for Medical Education and Research; 2019	The three mechanisms of disease associated with these C9orf72 repeats are deposition of RNA transcripts in the nucleus, translation of the RNA into toxic dipeptide repeat proteins in the cytoplasm, and decreased levels of the normal C9orf72 protein

There is a tentative association with exposure to various , including the , , , and

"Epidemiology of amyotrophic lateral sclerosis: A review of literature"

: Mayo Foundation for Medical Education and Research; 2019

The three mechanisms of disease associated with these C9orf72 repeats are deposition of RNA transcripts in the nucleus, translation of the RNA into toxic dipeptide repeat proteins in the cytoplasm, and decreased levels of the normal C9orf72 protein

Checkoway H, Lundin JI, Kelada SN 2011.

الدكتورة نجوى البستاني لـ التصلب الجانبي الضموري يحدث تدريجياً وعلاجاته الحالية محدودة الفاعلية: There is debate over whether PLS and PMA are separate diseases or simply variants of ALS
التصلب الجانبي الضموري (ALS) بأسبابه وأنواعه مع العلاج: A 2006 randomized controlled trial found that NIV prolongs survival by about 48 days and improves quality of life; however, it also found that some people with ALS benefit more from this intervention than others
التصلب الجانبي الضموري: الأعراض، الأسباب والعل: It is now possible to generate iPSCs from people with ALS, which can then be converted into spinal motor neurons, which are useful for studying disease mechanisms and for testing potential drugs for ALS

"Clinical significance in the change of decline in ALSFRS-R"	Journal of the Neurological Sciences
Zou ZY, Liu CY, Che CH, Huang HP January 2016	However, research published in 2021 suggested that there was a positive causal relationship between ALS and intense physical exercise in those with a risk genotype

"Clinical significance in the change of decline in ALSFRS-R"

Journal of the Neurological Sciences

Zou ZY, Liu CY, Che CH, Huang HP January 2016

However, research published in 2021 suggested that there was a positive causal relationship between ALS and intense physical exercise in those with a risk genotype

Two small studies have shown that people with isolated bulbar ALS may live longer than people with bulbar-onset ALS.

التصلب الجانبي الضموري : الأعراض ، المسار والمتخصصون: Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
Amyotrophic lateral sclerosis: Definite ALS was defined as upper motor neuron UMN and lower motor neuron LMN signs in three spinal cord regions, probable ALS as UMN and LMN signs in two regions, possible ALS as UMN and LMN signs in only one region, and suspected ALS as LMN signs only
تصلب جانبي ضموري: Sultan Qaboos University Medical Journal

The El Escorial Revised criteria are specific for ALS, which means that someone who meets the criteria is very likely to have ALS; however, they are not especially sensitive for ALS, which means that someone who does not meet the criteria can still have ALS	Speech-language pathologists may also help people diagnosed with ALS with their swallowing impairment dysphagia which may include modified diet, swallowing exercises, compensatory strategies
These regional variants of ALS cannot be diagnosed at the onset of symptoms; a failure of the disease to spread to other spinal cord regions for an extended period of time at least 12 months must be observed	The genes known to be involved in ALS can be grouped into three general categories based on their normal function: protein degradation, the , and RNA processing

The El Escorial Revised criteria are specific for ALS, which means that someone who meets the criteria is very likely to have ALS; however, they are not especially sensitive for ALS, which means that someone who does not meet the criteria can still have ALS

Speech-language pathologists may also help people diagnosed with ALS with their swallowing impairment dysphagia which may include modified diet, swallowing exercises, compensatory strategies

These regional variants of ALS cannot be diagnosed at the onset of symptoms; a failure of the disease to spread to other spinal cord regions for an extended period of time at least 12 months must be observed

The genes known to be involved in ALS can be grouped into three general categories based on their normal function: protein degradation, the , and RNA processing

Continuous positive pressure is not recommended for people with ALS because it makes breathing more difficult.

Amyotrophic lateral sclerosis: A 2017 review concluded that was safe and effective for treating cramps in ALS based on a randomized controlled trial from 2016
مرض التصلب الضموري العضلي الجانبي,علاج التصلب الضموري العضلي: "How amyotrophic lateral sclerosis got its name: the clinical-pathologic genius of Jean-Martin Charcot"
مرض التصلب الضموري العضلي الجانبي,علاج التصلب الضموري العضلي: In ALS with frontotemporal dementia, neurons throughout the frontal and temporal lobes of the brain die as well