| 1 Department of Internal Medicine, Division of Hematology, Maastricht University Medical Center, and mirelle | Keywords: DLL4 protein; T cell precursor; adoptive cellular immunotherapy; transplantation |
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| Causes of anemia in patients with cancer | Iriguchi S, Yasui Y, Kawai Y, Arima S, Kunitomo M, Sato T, Ueda T, Minagawa A, Mishima Y, Yanagawa N, Baba Y, Miyake Y, Nakayama K, Takiguchi M, Shinohara T, Nakatsura T, Yasukawa M, Kassai Y, Hayashi A, Kaneko S |
Adoptive transfer of in vitro-generated human T cell progenitors seems a promising approach to accelerate T cell recovery in immunocompromised patients.
11| AA may enhance T cell proliferation and differentiation in a controlled, feeder-free environment containing Notch ligands and defined growth factors | |
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| We conclude that neither DLL4-expressing feeder cells nor feeder cell conditioned media are required for generating DP T cells from CB and G-CSF-mobilized HSCs and that generation and proliferation of proT and DP T cells are greatly improved by AA | 2021 Jan 18;12 1 :430 |
Chemotherapy and you: Support for people with cancer.
30| Understanding your complete blood count CBC test | AA promotes the transition of proT1 to proT2 cells and of preT to DP T cells |
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| In particular, T cell regeneration is generally delayed, resulting in high infection-related mortality in the first years post-transplantation | This technology could potentially be used to generate T cell progenitors for adoptive therapy |
Our experiments show a pivotal role for AA during human in vitro T cell development.
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